Deeply influenced by the first game in the series, Desperados: Wanted Dead or Alive, Desperados III allows you to approach each mission with a wide variety of solutions and paths. Since the player's gang is always outnumbered, only the intelligent use of the environment and the unique character of each desperado ensure victory.

You take control of a rebellious gang that transforms into a highly functional team of heroes and heroines. The very different and strong personalities struggle to cooperate at first, but eventually, they join forces to combine their unique specialties and face a seemingly superior opponent. Hunted by ruthless gangs and corrupt lawmen, the desperados must turn the odds in their favor in every mission.