Maintaining Harrison's goals, this edition has been extensively modified in light of the various needs of the book's readers, as well as the multiple methods and forms through which information is now acquired and used.

The focus of medical education worldwide is shifting from the classical approach of structure/function/disease to a comprehensive, often case-based approach, in which positive and population sciences are specifically linked to practical diagnosis and management of disease.

A significant part of the updates and changes described here has been made with consideration of modern educational and clinical environments. The current new edition offers a thoroughly updated presentation of the classical pathophysiological basis of clinical medicine and details cutting-edge methods and tools that are now available for symptom assessment and effective disease management in today's healthcare environment.

The main text is complemented by new photographs, X-rays, images, charts, specialized algorithms for patient care, tables, as well as practical informational videos. Aiming to make the book as user-friendly as possible, a new referral system has been employed. Detailed bibliographic lists, with summaries of relevant articles, are available in the online version, replacing the general and limited collection of individual bibliographic sources.

The 19th edition of "Internal Medicine" continues a long-standing tradition and successful path and, renewed and updated with recent scientific discoveries, comes to claim a place in the library of the medical student, as well as the clinical physician or nurse. Volume 3 focuses on diseases by organ system.

Specifically, it examines disorders of the cardiovascular system, the respiratory system, the kidneys, the urinary tract, and the gastrointestinal system. The chapter on chronic hepatitis discusses in detail the impressive new discoveries in the use of direct-acting antiviral agents for the treatment of hepatitis C. These agents are responsible for some of the most exciting therapeutic methods.

New chapters in the 19th edition address topics such as renal vascular disease, non-alcoholic fatty liver disease, and non-alcoholic steatohepatitis. Complementing the new content and updates on diseases and patient care, the new videos in this edition cover, among other things, non-invasive cardiac imaging and the examination of a comatose patient.

The new atlases include non-invasive imaging, percutaneous revascularization, and gastrointestinal endoscopy.

Contents:

Part 10: Disorders of the cardiovascular system

Part 11: Disorders of the respiratory system

Part 12: Intensive care

Part 13: Disorders of the kidneys and urinary tract

Part 14: Disorders of the gastrointestinal system