BLAME! 1

In a future version of Earth, there exists a city that has developed so chaotically large that its inhabitants can no longer remember what "ground" means. Inside this mega-structure, the silent and calm Kyrii has undertaken a mission to find the Net Terminal Gene—a genetic mutation that in the past allowed humans to access the circuit-based NetSphere. Equipped with a powerful Emitter Graviton Beam, Kyrii fends off waves of attacks from other humans, government entities, and silicon-based life. Along the way, he meets an extraordinarily skilled scientist whose body has decayed from a long-term imprisonment, who promises to help Kyrii find the Net Terminal Gene, once she settles a personal matter for herself...