The game begins relatively calmly with 50 Cent giving a concert somewhere in the Middle East. After the concert, 50 Cent goes to receive his payment. However, the concert organizer is unable to pay in cash and instead offers 50 Cent a skull adorned with diamonds. Suddenly, the transaction is interrupted by an attack from unknown assailants, with a mysterious woman seizing the precious skull amidst the chaos and a hail of bullets!