In James Bond Bloodstone, players take on the role of agent 007 who teams up with the wealthy socialite Nicole Hunter to find the researcher Dr. Malcolm Tedworth who is presumed dead.

The story revolves around a global conspiracy taking place in the United Kingdom concerning a biochemical weapon.

James Bond, along with Nicole Hunter, must face terrorists and spies to find out who possesses the biochemical weapon before it ends up in the hands of a terrorist group led by someone named Greco.