In November 2019, Paul B. Preciado speaks before 3,500 psychoanalysts at the annual conference of the School of the Freudian Cause in Paris. He stands before a profession that sees him as a mentally ill individual suffering from gender dysphoria and begins his talk drawing inspiration from Kafka's "Report to an Academy," in which an ape explains at a scientific conference how, in order to survive in human society, he was forced to lock himself in the cage of human subjectivity, sinking into sorrow and alcoholism.

Speaking from his own "mutated" cage, Preciado attempts to show that we are in a time when the epistemological paradigm of gender difference is changing, and thus the scientific tools and fundamental concepts of psychoanalysis are in deep crisis. This crisis reveals the historicity and therefore the relativity of psychoanalytic concepts, as well as their deep connections to patriarchy and colonialism.

Preciado calls for a radical transformation of psychiatric and psychoanalytic discourses and practices, advocating for a new epistemology that will accept the multiplicity of bodies without reducing them to their exclusively heterosexual reproductive capacity, and without legitimizing heteropatriarchal and colonial violence.