Medicine, in the early 1800s, was a brutal business. Operations were performed without anaesthesia while conventional treatment relied on leeches, cupping and toxic potions. The most surgeons could offer by way of pain relief was a large swig of brandy.

Onto this scene came John Elliotson, the dazzling new hope of the medical world. Charismatic and ambitious, Elliotson was determined to transform medicine from a hodge-podge of archaic remedies into a practice informed by the latest science. In this aim he was backed by Thomas Wakley, founder of the new magazine, theLancet, and a campaigner against corruption and malpractice.