The story of Puzzle Bobble Everybubble! brings Bub, Bob, Peb, and Pab to the Rainbow Islands, where Miniroon, a mysterious character resembling Bub, lives. One day, Miniroon suddenly starts making bubbles, covering the entire island with them and causing trouble for its inhabitants.

It's time for the four friendly dragons to step up and help Miniroon stop the bubble-making nonsense! In this new adventure, players must once again clear the bubbles in a series of increasingly challenging and fun stages. To aid them in their mission, players will be able to use numerous items and tricks, or try to do their best on their own.