The The Lord of the Rings: Tales of Middle-earth Set Booster Box contains 30 Set Boosters as well as 1 Traditional Foil Box Topper card. Each Set Booster contains 12 Magic cards, 1 Art Card, and 1 token/ad card, Helper card, or card from the "List" (a special card from the history of Magic, found in 25% of the packs).

Each pack includes a combination of 1–4 cards of Rare rarity or higher, 3–7 Uncommon, 3–7 Common, and 1 Land card. A Traditional Foil Land replaces the basic land in 20% of the Set Boosters, and a Foil-Stamped Signature Art Card replaces the Art Card in 10% of the Set Boosters.