For therapeutic purposes, the dried leaves and stems are used.

The herb acts as a neurotonic, antidepressant, antiseptic for the urinary tract, and laxative.

In modern herbal medicine, Damiana is primarily used as a body enhancer and for addressing nervous disorders. The bitter substance damianin has the property of stimulating the nervous system, making it suitable for cases of intense anxiety, nervousness, lethargy, and mild forms of depression. The stimulation of the nervous system is often accompanied by a general sense of euphoria and rejuvenation of the entire body.

The pharmacology of the plant indicates that its alkaloids may have effects similar to those of testosterone. It is a useful antidepressant that is particularly effective in cases of anxiety and depression when there is a sexual factor involved.

It can be used to strengthen the male reproductive system. As a neurotonic, it is often used in combination with oats in cases of general depression.