Explores the united science-religion of early humanity and the influence of Hermetic philosophy on religion and spirituality. Investigates the Jewish and Egyptian origins of the famous story by Josephus that the descendants of Seth recorded knowledge on two pillars to save it from global catastrophe. Reveals how this primordial knowledge has influenced culture through Hermetic, Gnostic, Kabbalistic, Masonic, Indian, and Islamic mystical knowledge. Examines how the "Pillars of Enoch" are related to the roots of Hermeticism, Freemasonry, Newtonian science, William Blake, and Theosophy. The esoteric tradition claims that at the dawn of human civilization, there was a united science-religion, a spiritual understanding of the universe and our place in it. The biblical Enoch—also known as Hermes Trismegistus, Thoth, or Idris—was considered the guardian of this sacred knowledge, recorded on pillars known as the Pillars of Enoch or Seth. Tobias Churton analyzes the concept of the lost pillars of pure knowledge, the sacred science behind Hermetic philosophy, by exploring the controversial Jewish and Egyptian roots of Josephus's famous story, and traces the fragments of this sacred knowledge as they descend through the ages, influencing culture. It follows the path of the fragments of the pillars through Egyptian alchemy and Gnostics, the Kabbalah, and the medieval mystic Ramon Llull. It explores the arrival of Hermetic manuscripts in Renaissance Florence, the philosophy of Copernicus, Pico della Mirandola, Giordano Bruno, and the roots of Freemasonry. Reveals the significance of primordial knowledge for Isaac Newton, William Stukeley, John Dee, and William Blake. Shows how the lost pillars stand as a 21st-century symbol for reclaiming our heritage, ultimately revealing how the inner strands of all religions unite in one knowledge that could provide a basis for the reunification of religion and science.