Five years after their dangerous journey across the post-pandemic United States, Ellie and Joel have settled in Jackson, Wyoming. Life in the thriving community of survivors has brought them peace and stability, despite the constant threat from the infected and other, more desperate survivors.

When a violent event disrupts this peace, Ellie embarks on a relentless journey to bring justice and closure. As she hunts down those responsible one by one, she faces the devastating physical and emotional repercussions of her actions.