A body has been found in an abandoned hotel in the Midwest, the latest in a mysterious series of deaths across the United States.

FBI intelligence analyst Grace Ashcroft has taken on the case, at the very place where her mother was murdered eight years ago. But when it is discovered that a police officer has disappeared in the hotel, veteran agent Leon S. Kennedy is also sent to the crime scene.

As Grace and Leon's paths converge, they must confront their past and uncover the truth behind the Raccoon City incident that changed the world forever. But while the horrors of their memories echo in their minds, will they relive the nightmare... or finally offer a requiem for the dead?