The story begins when Lara Croft and archaeologist Carter Bell enter an Egyptian temple and remove the Mythical Staff, accidentally releasing Set, the god of chaos, and triggering a curse that traps them in the underworld. However, the staff awakens the gods Isis and Horus, who team up with humans to stop Set and restore balance.

The game supports up to 4-player co-op, with each character having unique abilities: Lara uses a grappling hook and firearms, the gods have magical powers, and Carter combines archaeological knowledge with combat. Players solve puzzles, avoid traps, and fight enemies in environments full of treasures and secrets. The gameplay combines platforming, shooting, and puzzle-solving, with competitive elements such as point collection and artifacts.